My research is focused on the study of the molecular mechanisms implicated in the development and spreading of pathological proteins (such as tau and α-synuclein) involved in the neurodegenerative process of Alzheimer´s and Parkinson´s diseases, respectively. In the next few years, I would like to start my independent scientific career in studying the effects of genetic variants in disease-associated risk genes such as ApoE, on the development and progression of α-synuclein and tau pathologies, as well as the mechanisms involved in the ApoE- increased risk/protection against clinical dementia development.

Van der Jeugd A, Parra-Damas A, Baeta-Corral R, Soto-Faguás CM, Ahmed T, LaFerla FM, Giménez-Llort L, D'Hooge R, Saura CA. Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice. Scientific Reports. 2018 Apr 24;8(1):6431. doi: 10.1038/s41598-018-24741-0. PMID: 29691439; PMCID: PMC5915484.

Florido A, Velasco ER, Soto-Faguás CM, Gomez-Gomez A, Perez-Caballero L, Molina P, Nadal R, Pozo OJ, Saura CA, Andero R. Sex differences in fear memory consolidation via Tac2 signaling in mice. Nature Communication. 2021 May 3;12(1):2496. doi: 10.1038/s41467-021-22911-9. PMID: 33941789; PMCID: PMC8093426.

Soto-Faguás CM, Sanchez-Molina P and Saura CA. Loss of presenilin function enhances tau phosphorylation and aggregation in mice. Acta Neuropathological Communications. 2021 Sep 30;9(1):162. doi: 10.1186/s40478-021-01259-7. PMID: 34593029; PMCID: PMC8482568.i

del Ser-Badia A*, Soto-Faguás CM*, Vecino R, Rodriguez-Alvarez J, Vicario C, Saura CA. Presenilin-dependent regulation of tau pathology via the autophagy/proteasome pathway. BiorXiv. 2023 Dec 23. doi: https://doi.org/10.1101/2023.12.21.572822