Additionally, I have a background in RNA biology, with a focus on RNA processing, quality control, and regulation. I am interested in understanding the molecular mechanisms underlying these processes, particularly in the context of disease, such as cancer and cardiovascular diseases. My previous work has explored the mechanisms and regulation of polyadenylation and alternative polyadenylation and their implications in disease pathogenesis.

Overall, my research aims to uncover fundamental insights into nucleic acid immunity and RNA biology, with the ultimate goal of contributing to our understanding of disease mechanisms and the development of novel therapeutic strategies.

piRNA generation is associated with the pioneer round of translation in stem cells

SA Parambil, D Li, M Zelko, A Poulet, JC van Wolfswinkel. Nucleic Acids Research

Star-PAP controls oncogene expression through primary miRNA 3′-end formation to regulate cellular proliferation and tumour formation

NK Mohanan, F Shaji, AP Sudheesh, AB Prabhashankar, NR Sundaresan, .... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1870 (4), 167080

Star-PAP controlled alternative polyadenylation coupled poly (A) tail length regulates protein expression in hypertrophic heart

AP Sudheesh, N Mohan, N Francis, RS Laishram, RA Anderson. Nucleic Acids Research 47 (20), 10771-10787

Nuclear phosphatidylinositol-phosphate type I kinase α-coupled star-PAP polyadenylation regulates cell invasion

AP Sudheesh, RS Laishram. Molecular and cellular biology

Phosphorylation regulates the Star-PAP-PIPKIα interaction and directs specificity toward mRNA targets

N Mohan, S AP, N Francis, R Anderson, RS Laishram. Nucleic acids research 43 (14), 7005-7020

CstF-64 and 3′-UTR cis-element determine Star-PAP specificity for target mRNA selection by excluding PAPα

DT Kandala, N Mohan, A Vivekanand, AP Sudheesh, G Reshmi, .... Nucleic Acids Research 47 (3), 1598