I am currently interested in investigating the regulation of extrachromosomal DNA amplifications (ecDNA) in cancer cells, as they are significant contributors to tumor pathogenesis, heterogeneity, and evolution, often leading to poor patient outcomes. My focus lies in unraveling the molecular drivers involved in ecDNA replication and the formation-dissociation cycle of ecDNA hubs, utilizing proximity labeling-based proteomic profiling. Additionally, I am dedicated to identifying shared features among general ecDNAs. Ultimately, my aim is to develop tools for ecDNA research and to devise novel therapeutic strategies targeting ecDNA-mediated oncogenesis.

In my graduate work, I concentrated on understanding the role of extracellular vesicles (EVs) in mediating the innate immune response. EVs, lipid-encapsulated vesicles secreted by various cell types, serve as important mediators in intercellular communication. Employing techniques such as super-resolution microscopy, mass spectrometry, and transmission electron microscopy, I investigated the mechanisms underlying EV biogenesis and uptake during Toll-like receptor (TLR) 9 activation and lipopolysaccharide (LPS) infection.

I am currently interested in investigating the regulation of extrachromosomal DNA amplifications (ecDNA) in cancer cells, as they are significant contributors to tumor pathogenesis, heterogeneity, and evolution, often leading to poor patient outcomes. My focus lies in unraveling the molecular drivers involved in ecDNA replication and the formation-dissociation cycle of ecDNA hubs, utilizing proximity labeling-based proteomic profiling. Additionally, I am dedicated to identifying shared features among general ecDNAs. Ultimately, my aim is to develop tools for ecDNA research and to devise novel therapeutic strategies targeting ecDNA-mediated oncogenesis.

In my graduate work, I concentrated on understanding the role of extracellular vesicles (EVs) in mediating the innate immune response. EVs, lipid-encapsulated vesicles secreted by various cell types, serve as important mediators in intercellular communication. Employing techniques such as super-resolution microscopy, mass spectrometry, and transmission electron microscopy, I investigated the mechanisms underlying EV biogenesis and uptake during Toll-like receptor (TLR) 9 activation and lipopolysaccharide (LPS) infection. Notably, my research on EV-mediated TLR9 activation has been published in Science Advances, with the final part accepted by the Journal of Extracellular Vesicles.